Multi SNP QTL MR evidence — xqtl_multi_snp

GET /xqtl/multi-snp-mr

xqtl_multi_snp_mr(
  exposure_gene = NULL,
  outcome_trait = NULL,
  mr_method = c("IVW", "Egger"),
  qtl_type = c("eQTL", "pQTL"),
  pval_threshold = 1e-05,
  mode = c("table", "raw")
)

Arguments

exposure_gene: Name of the exposure gene
outcome_trait: Name of the outcome trait
mr_method: "IVW" or "Egger"
qtl_type: "eQTL" or "pQTL"
pval_threshold: P-value threshold
mode: If mode = "table", returns a data frame (a tibble as per tidyverse convention). If mode = "raw", returns a raw response from EpiGraphDB API with minimal parsing done by httr.

Value

Data from GET /xqtl/multi-snp-mr

Examples

# \dontrun{
xqtl_multi_snp_mr(outcome_trait = "Coronary heart disease")
#> # A tibble: 11 × 7
#>    gene.ensembl_id gene.name    gwas.id gwas.trait        r.beta   r.se      r.p
#>    <chr>           <chr>        <chr>   <chr>              <dbl>  <dbl>    <dbl>
#>  1 ENSG00000134222 PSRC1        ieu-a-7 Coronary heart … -0.214  0.0270 1.98e-15
#>  2 ENSG00000183508 FAM46C       ieu-a-7 Coronary heart …  0.236  0.0435 5.86e- 8
#>  3 ENSG00000151612 ZNF827       ieu-a-7 Coronary heart … -0.503  0.0968 2.05e- 7
#>  4 ENSG00000133789 SWAP70       ieu-a-7 Coronary heart … -0.184  0.0361 3.24e- 7
#>  5 ENSG00000130475 FCHO1        ieu-a-7 Coronary heart … -0.127  0.0257 7.28e- 7
#>  6 ENSG00000076685 NT5C2        ieu-a-7 Coronary heart … -0.148  0.0303 1.08e- 6
#>  7 ENSG00000212541 RNU6-510P    ieu-a-7 Coronary heart … -0.0912 0.0194 2.50e- 6
#>  8 ENSG00000152804 HHEX         ieu-a-7 Coronary heart … -0.174  0.0371 2.82e- 6
#>  9 ENSG00000197520 FAM177B      ieu-a-7 Coronary heart …  0.237  0.0510 3.32e- 6
#> 10 ENSG00000234608 MAPKAPK5-AS1 ieu-a-7 Coronary heart … -0.142  0.0308 4.25e- 6
#> 11 ENSG00000242142 SERBP1P3     ieu-a-7 Coronary heart …  0.0683 0.0150 5.17e- 6
# }