xqtl_multi_snp_mr(
  exposure_gene = NULL,
  outcome_trait = NULL,
  mr_method = c("IVW", "Egger"),
  qtl_type = c("eQTL", "pQTL"),
  pval_threshold = 1e-05,
  mode = c("table", "raw")
)

Arguments

exposure_gene

Name of the exposure gene

outcome_trait

Name of the outcome trait

mr_method

"IVW" or "Egger"

qtl_type

"eQTL" or "pQTL"

pval_threshold

P-value threshold

mode

If mode = "table", returns a data frame (a tibble as per tidyverse convention). If mode = "raw", returns a raw response from EpiGraphDB API with minimal parsing done by httr.

Value

Data from GET /xqtl/multi-snp-mr

Examples

xqtl_multi_snp_mr(outcome_trait = "Coronary heart disease")
#> # A tibble: 11 x 7 #> gene.ensembl_id gene.name gwas.id gwas.trait r.beta r.se r.p #> <chr> <chr> <chr> <chr> <dbl> <dbl> <dbl> #> 1 ENSG00000134222 PSRC1 ieu-a-7 Coronary heart d… -0.214 0.0270 1.98e-15 #> 2 ENSG00000183508 FAM46C ieu-a-7 Coronary heart d… 0.236 0.0435 5.86e- 8 #> 3 ENSG00000151612 ZNF827 ieu-a-7 Coronary heart d… -0.503 0.0968 2.05e- 7 #> 4 ENSG00000133789 SWAP70 ieu-a-7 Coronary heart d… -0.184 0.0361 3.24e- 7 #> 5 ENSG00000130475 FCHO1 ieu-a-7 Coronary heart d… -0.127 0.0257 7.28e- 7 #> 6 ENSG00000076685 NT5C2 ieu-a-7 Coronary heart d… -0.148 0.0303 1.08e- 6 #> 7 ENSG00000212541 RNU6-510P ieu-a-7 Coronary heart d… -0.0912 0.0194 2.50e- 6 #> 8 ENSG00000152804 HHEX ieu-a-7 Coronary heart d… -0.174 0.0371 2.82e- 6 #> 9 ENSG00000197520 FAM177B ieu-a-7 Coronary heart d… 0.237 0.0510 3.32e- 6 #> 10 ENSG00000234608 MAPKAPK5-A… ieu-a-7 Coronary heart d… -0.142 0.0308 4.25e- 6 #> 11 ENSG00000242142 SERBP1P3 ieu-a-7 Coronary heart d… 0.0683 0.0150 5.17e- 6