Multi SNP QTL MR evidence

GET /xqtl/multi-snp-mr

xqtl_multi_snp_mr(
  exposure_gene = NULL,
  outcome_trait = NULL,
  mr_method = c("IVW", "Egger"),
  qtl_type = c("eQTL", "pQTL"),
  pval_threshold = 1e-05,
  mode = c("table", "raw")
)

Arguments

exposure_gene	Name of the exposure gene
outcome_trait	Name of the outcome trait
mr_method	"IVW" or "Egger"
qtl_type	"eQTL" or "pQTL"
pval_threshold	P-value threshold
mode	If mode = "table", returns a data frame (a tibble as per tidyverse convention). If mode = "raw", returns a raw response from EpiGraphDB API with minimal parsing done by httr.

Value

Data from GET /xqtl/multi-snp-mr

Examples

xqtl_multi_snp_mr(outcome_trait = "Coronary heart disease")
#> # A tibble: 11 x 7
#>    gene.ensembl_id gene.name   gwas.id gwas.trait         r.beta   r.se      r.p
#>    <chr>           <chr>       <chr>   <chr>               <dbl>  <dbl>    <dbl>
#>  1 ENSG00000134222 PSRC1       ieu-a-7 Coronary heart d… -0.214  0.0270 1.98e-15
#>  2 ENSG00000183508 FAM46C      ieu-a-7 Coronary heart d…  0.236  0.0435 5.86e- 8
#>  3 ENSG00000151612 ZNF827      ieu-a-7 Coronary heart d… -0.503  0.0968 2.05e- 7
#>  4 ENSG00000133789 SWAP70      ieu-a-7 Coronary heart d… -0.184  0.0361 3.24e- 7
#>  5 ENSG00000130475 FCHO1       ieu-a-7 Coronary heart d… -0.127  0.0257 7.28e- 7
#>  6 ENSG00000076685 NT5C2       ieu-a-7 Coronary heart d… -0.148  0.0303 1.08e- 6
#>  7 ENSG00000212541 RNU6-510P   ieu-a-7 Coronary heart d… -0.0912 0.0194 2.50e- 6
#>  8 ENSG00000152804 HHEX        ieu-a-7 Coronary heart d… -0.174  0.0371 2.82e- 6
#>  9 ENSG00000197520 FAM177B     ieu-a-7 Coronary heart d…  0.237  0.0510 3.32e- 6
#> 10 ENSG00000234608 MAPKAPK5-A… ieu-a-7 Coronary heart d… -0.142  0.0308 4.25e- 6
#> 11 ENSG00000242142 SERBP1P3    ieu-a-7 Coronary heart d…  0.0683 0.0150 5.17e- 6