The function proceeds as follows:
Select features (by default this is done using LASSO feature selection).
Subset the mvdat to only retain relevant features and instruments.
Perform MVMR on remaining data.
Usage
mv_subset(
mvdat,
features = mv_lasso_feature_selection(mvdat),
intercept = FALSE,
instrument_specific = FALSE,
pval_threshold = 5e-08,
plots = FALSE
)Arguments
- mvdat
Output from
mv_harmonise_data().- features
Dataframe of features to retain, must have column with name 'exposure' that has list of exposures to retain from mvdat. The default is
mvdat_lasso_feature_selection(mvdat).- intercept
Should the intercept by estimated (
TRUE) or force line through the origin (FALSE, the default).- instrument_specific
Should the estimate for each exposure be obtained by using all instruments from all exposures (
FALSE, default) or by using only the instruments specific to each exposure (TRUE).- pval_threshold
P-value threshold to include instruments. The default is
5e-8.- plots
Create plots? The default is
FALSE.