Performs initial multivariable MR analysis from Burgess et al 2015. For each exposure the outcome is residualised for all the other exposures, then unweighted regression is applied.
Usage
mv_residual(
mvdat,
intercept = FALSE,
instrument_specific = FALSE,
pval_threshold = 5e-08,
plots = FALSE
)Arguments
- mvdat
Output from
mv_harmonise_data().- intercept
Should the intercept by estimated (
TRUE) or force line through the origin (FALSE, default).- instrument_specific
Should the estimate for each exposure be obtained by using all instruments from all exposures (
FALSE, default) or by using only the instruments specific to each exposure (TRUE).- pval_threshold
P-value threshold to include instruments. The default is
5e-8.- plots
Create plots? The default is
FALSE.