Performs modified multivariable MR analysis. For each exposure the instruments are selected then all exposures for those SNPs are regressed against the outcome together, weighting for the inverse variance of the outcome.

mv_multiple(
  mvdat,
  intercept = FALSE,
  instrument_specific = FALSE,
  pval_threshold = 5e-08,
  plots = FALSE
)

Arguments

mvdat

Output from mv_harmonise_data.

intercept

Should the intercept by estimated (TRUE) or force line through the origin (FALSE, default).

instrument_specific

Should the estimate for each exposure be obtained by using all instruments from all exposures (FALSE, default) or by using only the instruments specific to each exposure (TRUE).

pval_threshold

P-value threshold to include instruments. The default is 5e-8.

plots

Create plots? The default is FALSE.

Value

List of results