MR weighted mode estimator (NOME) — mr_weighted_mode_nome • TwoSampleMR

Weighted mode estimator

Usage

mr_weighted_mode_nome(
  b_exp,
  b_out,
  se_exp,
  se_out,
  parameters = default_parameters()
)

Arguments

b_exp: Vector of genetic effects on exposure
b_out: Vector of genetic effects on outcome
se_exp: Standard errors of genetic effects on exposure
se_out: Standard errors of genetic effects on outcome
parameters: List containing phi - Bandwidth parameter, and nboot - number of bootstraps to calculate SE. default_parameters() sets list(phi=1, nboot=1000).

Value

List with the following elements:

b: MR estimate
se: Standard error
pval: p-value