Perform MR using summary statistics. Bootstraps used to calculate standard error.

mr_weighted_median(
  b_exp,
  b_out,
  se_exp,
  se_out,
  parameters = default_parameters()
)

Arguments

b_exp

Vector of genetic effects on exposure.

b_out

Vector of genetic effects on outcome.

se_exp

Standard errors of genetic effects on exposure.

se_out

Standard errors of genetic effects on outcome.

parameters

The default is default_parameters(). Specify the number of bootstrap replications to calculate the SE with nboot. The default is list(nboot=1000).

Value

List with the following elements:

b

MR estimate

se

Standard error

pval

p-value