Weighted median method — mr_weighted_median • TwoSampleMR

Perform MR using summary statistics. Bootstraps used to calculate standard error.

Usage

mr_weighted_median(
  b_exp,
  b_out,
  se_exp,
  se_out,
  parameters = default_parameters()
)

Arguments

b_exp: Vector of genetic effects on exposure.
b_out: Vector of genetic effects on outcome.
se_exp: Standard errors of genetic effects on exposure.
se_out: Standard errors of genetic effects on outcome.
parameters: The default is default_parameters(). Specify the number of bootstrap replications to calculate the SE with nboot. The default is list(nboot=1000).

Value

List with the following elements:

b: MR estimate
se: Standard error
pval: p-value