Simple median method — mr_simple_median • TwoSampleMR

Perform MR using summary statistics. Bootstraps used to calculate standard error.

Usage

mr_simple_median(
  b_exp,
  b_out,
  se_exp,
  se_out,
  parameters = default_parameters()
)

Arguments

b_exp: Vector of genetic effects on exposure.
b_out: Vector of genetic effects on outcome.
se_exp: Standard errors of genetic effects on exposure.
se_out: Standard errors of genetic effects on outcome.
parameters: The number of bootstrap replications used to calculate the SE can be set through parameters=list(nboot = 1000). The default is list(nboot=1000).

Value

List with the following elements:

b: MR estimate
se: Standard error
pval: p-value
nsnp: The number of SNPs