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Bivariate LDSC

Source: R/ldsc.r
ldsc_rg_internal.Rd

Imported here to help estimate sample overlap between studies

Usage

ldsc_rg_internal(Zs, r2, h1, h2, N1, N2, Nc = 0, W = NULL)

Arguments

Zs

Mx2 matrix of summary Z-statistics for M variants from two GWAS

r2

average reference LD scores for M variants

h1

hsq for trait 1

h2

hsq for trait 2

N1

sample size for the 1st GWAS

N2

sample size for the 2nd GWAS

Nc

overlapped sample size between the two GWAS

W

variant weight

Value

List of models

References

Bulik-Sullivan,B.K. et al. (2015) An atlas of genetic correlations across human diseases and traits. Nat. Genet. 47, 1236–1241.

Guo,B. and Wu,B. (2018) Principal component based adaptive association test of multiple traits using GWAS summary statistics. bioRxiv 269597; doi: 10.1101/269597

Gua,B. and Wu,B. (2019) Integrate multiple traits to detect novel trait-gene association using GWAS summary data with an adaptive test approach. Bioinformatics. 2019 Jul 1;35(13):2251-2257. doi: 10.1093/bioinformatics/bty961.

https://github.com/baolinwu/MTAR