Perform clumping on the chosen variants using through API
Usage
ld_clump_api(
dat,
clump_kb = 10000,
clump_r2 = 0.1,
clump_p,
pop = "EUR",
opengwas_jwt = get_opengwas_jwt()
)
Arguments
- dat
Dataframe. Must have a variant name column (
variant
) and pval column calledpval
. Ifid
is present then clumping will be done per unique id.- clump_kb
Clumping kb window. Default is very strict,
10000
- clump_r2
Clumping r2 threshold. Default is very strict,
0.001
- clump_p
Clumping sig level for index variants. Default =
1
(i.e. no threshold)- pop
Super-population to use as reference panel. Default =
"EUR"
. Options are"EUR"
,"SAS"
,"EAS"
,"AFR"
,"AMR"
- opengwas_jwt
Used to authenticate protected endpoints. Login to https://api.opengwas.io to obtain a jwt. Provide the jwt string here, or store in .Renviron under the keyname OPENGWAS_JWT.#' @param bfile If this is provided then will use the API. Default =
NULL