Perform clumping on the chosen variants using through API
Usage
ld_clump_api(
dat,
clump_kb = 10000,
clump_r2 = 0.1,
clump_p,
pop = "EUR",
opengwas_jwt = get_opengwas_jwt(),
...
)Arguments
- dat
Dataframe. Must have a variant name column (
variant) and pval column calledpval. Ifidis present then clumping will be done per unique id.- clump_kb
Clumping kb window. Default is very strict,
10000- clump_r2
Clumping r2 threshold. Default is very strict,
0.001- clump_p
Clumping sig level for index variants. Default =
1(i.e. no threshold)- pop
Super-population to use as reference panel. Default =
"EUR". Options are"EUR","SAS","EAS","AFR","AMR"- opengwas_jwt
Used to authenticate protected endpoints. Login to https://api.opengwas.io to obtain a jwt. Provide the jwt string here, or store in .Renviron under the keyname OPENGWAS_JWT.
- ...
Additional arguments passed to
api_query().